Research
The group is interested in understanding how signaling networks are rewired in complex diseases and specifically in cancer. We aim to obtain cell-specific models describing how signalling pathways and gene regulatory networks lead to the establishment of different phenotypes.
Our lab combines bioinformatic approaches with mass spectrometry-based phosphoproteomics, deep sequencing and multi-parametric analysis to address the following questiions:
What are the molecular mechanisms driving tyrosine kinase inhibitor resistance in FLT3-ITD dependent Acute Myeloid Leukemia?
What are the molecular mechanisms underlying imatinib resistance in Chronic Myeloid Leukemia?
Can we "illuminate" the dark kinases? Is it possible to identify novel substrates of poorly characterised kinases?
Our lab collaborates with the MS facilty at TIGEM, wherein Francesca Sacco is the coordinator of Phosphoproteomics